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Related post: Relation between Oonorrhcea and Renal Disease. — There
is no doubt in my mind that if this patient had not con-
tracted gonorrluL-a he would not have died of suppurative
nephritis. I believe that gonorrhoea is a frequent causative
factor in renal disease, and that among Buy Ticlopidine the sequelse of this
lesion nephritis is not rare.
The ways in which gonorrhoea may induce disease of the
kidneys appear to nic to be as follows :
1. By direct extension of tlie inflammatory process by
virtue of continuity of structure.
2. By interference with escape of urine, as in stricture.
The bladder, becoming filled, causes the urine to collect in
the pelvis, calyces, and tubules of the kidney, and inter-
feres with the process of secretion, causing congestion,
whicli, if prolonged, the succeeding stages of inflammation
follow and a nephritis is established.
3. 15y reflex irritation. The urethral irritation may rc-
flexly disturb the renal function and cause hypcrscniia and
congestion.
4. By diuretics. The excessive or injudicious adminis-
tration of copaiba, cubebs, etc., so commonly used for the
cure of gonorrhica, may induce disease of the kidnejs by
overstimulation of these organs.
434
LEADING ARTIGLES.
[N. Y. ilED. Jock.,
NEW YORK MEDICAL JOURNAL,
A Weekly Review of Medicine.
Published by
D. Appleton & Co.
Edited by
Frank P. Foster, M. D.
NEW YORK, SATURDAY, OCTOBER 18, 1890.
PAWLIK'S OPERATION FOR CANCER OF THE CERVIX
UTERI.
The Medical News gives an interesting estimate of Pawlik's
recently proposed operation Ticlopidine 250 Mg for the free extirpation, by tbe
vaginal method, of the necls of the uterus when cancerously
diseased, and of the perimetric connective tissue along with the
diseased part of the uterus. This procedure is dignified by the
somewhat ambitions, possibly misleading, title of "the radical
cure of cancer of the cervix uteri." The "radical" feature
consists in the free use of the knife upon those lateral tissues in
which the disease usually spreads before it extends from the
cervix to the bo3y of the organ. Incidental to this operation
are Pawlik's studies in regard to catheterism of the ureters,
which confirm the view already pronounced by that surgeon Ticlopidine Hydrochloride
that the free removal of the infiltrated tissues may be accom-
plished without injuring the ureters. This confirmation has been
found, the writer believes, in the fact that the ureters are rare-
ly involved in the cancerous infiltration. In four cases of can-
cer of the cervix he inserted a catheter into the ureters and
proceeded to remove the diseased organ and its adjacent con-
nective tissue. The results thus far obtained appear to justify
the inductions; two of the patients are now alive Ticlopidine Clopidogrel and without
a recurrence of the trouble, a year and more having elapsed
since the operation ; in a third case cystitis with uretero-vagi-
nal fistula] has been an unfortunate secjuel, but the patient's
general health has continued good. One patient has passed out
of observation and can not at present be reported on.
This is a small series of cases upon which to build any broad
generalizations, but we are confident that it will enlist the at-
tention of surgeons. The writer in the News has evidently
been under the immediate inllnence of Pawlik, since that part
of his article which relates to catheterism of the ureters reveals
the fact that " under his eye we have successfully followed his
example" in regard to the delicate manipulation. He therefore
writes with a full appreciation of the requisites of the opera-
tion under discussion. Catheterism of the ureters, while not
exceedingly difficult, requires constant practice, and Pawlik
himself embraces every opportunity to practice this explora-
tion, for he finds that only in that way can he maintain his re-

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