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Related post: CH,
I
CO
I
CH„
+
n.,0
COOH
Diacetic acid.
Diacetic acid asfain is readily decomposed into ace-
tone and carbon dioxide as follows:
CH.,
I
CO
I
CHo
COOH
Diacetic aciil.
CH3
I
CO
+
CO..
CH,
Acetone.
822
FUTCHER: DIABETIC COMA.
[N. Y. Med. Jock.,
In 1857, Buy Divalproex Online Fetters, an assistant of the elder von Jakscli,
detected in the urine of a fatal case of diahetes a sub-
stance which in its reactions with sulphuric Generic Divalproex acid and
caustic alkalies resembled acetone. The alcoholic or
fruity odor of the urine in certain cases of diabetes had
been previously recognized. Under Lerch's direction it
was further shown that a similar substance was contained
in the blood of some patients. The identity of this sub-
stance with acetone was later proved by Kaulich and
Tollens, and subsequently confirmed by Cantani and
Fleischer. Fetters and Kaulich believed that acetone
was produced by some abnormal fermentation in the
intestine, but Kussmaul showed that this could not be
true. Von Jaksch, Jr., who made a careful study of the
occurrence of acetone in the urine, concluded that it was
present in minute traces in the urine of healthy indi-
viduals (a view not universally accepted), and Salkowslii
subsequently showed that any healthy urine when dis-
tilled with sulphuric acid yields a Buy Divalproex substance which gives
all the reactions of acetone. The detection of acetone
in the urine of patients suffering from diabetic coma
at first led observers to believe that it was the cause
of this complication, a view no longer held. Since it
has been shown that acetone can be administered to ani-
mals in considerable quantities without producing toxic
symptoms. Further, it has been found in the urine in
quite a variety of other diseases, particularly in severe
cachexias, as in that following carcinoma, and also in
small-pox, typhus, pneumonia, scarlet fever, and measles,
without giving rise to symptoms resembling those of
diabetic coma. The most that can be said at present re-
garding the appearance of acetone in the urine is that

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